26 out of 91
Racemic mixture of two enantiomers with different pharmacokinetic and pharmacodynamic properties is seen in (AIPG 2012)
Ans. C Verapamil
- Goodman and Gillman describes verapamil as:
- Verapamil is prescribed as a racemate.
- “Verapamil is a more potent calcium channel blocker than d-verapamil.”
- For this reason, a given concentration of verapamil prolongs the PR interval to a greater extent when the drug is administered intravenously (where conc. of 1- and d- enantiomers are equivalent) that when it is administered orally.