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Medicine

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Kidney

Question
15 out of 20
 

Ramlal, a 65 years male, a known case of Ca colon complains of generalized swelling in his body. His urine examination shows proteinuria of 4 gm/ 24 hours. Which type of Glomerulonephritis is most likely to be cause in this?



A Minimal change
B Membranous

C Focal & segmental
D Membrane proliferative

Ans. B Membranous
B. Membranous GN (Ref. H-18th Edi, P- 2347)

This occur commonly in adults

Conditions Associated with Membranous Glomerulopathy

1. Idiopathic (majority)

2. Infection: Hepatitis B and C, secondary and congenital syphilis, malaria, schistosomiasis, leprosy, hydatid disease, filariasis, enterococcal endocarditis

3. Systemic autoimmune diseases

SLE, rheumatoid disease, Sjorgren’s syndrome, Hashimoto’s disease, Graves’ disease, mixed

connective tissue disease, primary biliary cirrhosis, ankylosing spondylitis, dermatitis

herpetiformis, bullous pemphigoid, myasthenia gravis

4. Neoplasia

Carcinoma of the breast, lung, colon, stomach, and esophagus; melanoma; renal cell

carcinoma; neuroblastoma; carotid body tumor

5. Drugs: Gold, penicillamine, captopril, NSAIDs, probenecid, trimethadione, chlormethiazole, mercury

6. Miscellaneous

i. Sarcoidosis ii. Diabetes mellitus iii. Sickle cell disease iv. Crohn’s disease v. Guillain – Barre syndrome

Clinical Features

i. Patients present with edema, nephrotic proteinuria and high BP.

ii. Renal insufficiency and abnormal urine sediment may develop later.

iii. Renal vein thrombosis is common.

iv. Complement levels are normal

C. Focal and Segmental Glomerulosclerosis (FSG)

Kidney Flashcard List

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