Ramlal, a 65 years male, a known case of Ca colon complains of generalized swelling in his body. His urine examination shows proteinuria of 4 gm/ 24 hours. Which type of Glomerulonephritis is most likely to be cause in this?
|C||Focal & segmental|
B. Membranous GN (Ref. H-18th Edi, P- 2347)
This occur commonly in adults
Conditions Associated with Membranous Glomerulopathy
1. Idiopathic (majority)
2. Infection: Hepatitis B and C, secondary and congenital syphilis, malaria, schistosomiasis, leprosy, hydatid disease, filariasis, enterococcal endocarditis
3. Systemic autoimmune diseases
SLE, rheumatoid disease, Sjorgren’s syndrome, Hashimoto’s disease, Graves’ disease, mixed
connective tissue disease, primary biliary cirrhosis, ankylosing spondylitis, dermatitis
herpetiformis, bullous pemphigoid, myasthenia gravis
Carcinoma of the breast, lung, colon, stomach, and esophagus; melanoma; renal cell
carcinoma; neuroblastoma; carotid body tumor
5. Drugs: Gold, penicillamine, captopril, NSAIDs, probenecid, trimethadione, chlormethiazole, mercury
i. Sarcoidosis ii. Diabetes mellitus iii. Sickle cell disease iv. Crohn’s disease v. Guillain – Barre syndrome
i. Patients present with edema, nephrotic proteinuria and high BP.
ii. Renal insufficiency and abnormal urine sediment may develop later.
iii. Renal vein thrombosis is common.
iv. Complement levels are normal
C. Focal and Segmental Glomerulosclerosis (FSG)