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Pathology

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Neoplasia

Question
14 out of 17
 

Rate of growth of tumor is determined by all except(LQ)



A Doubling time of tumor cells

B Fraction of tumor cells that are in replicative pool

C Rate at which the cells shed or die

D Shortening of cell cycle

Ans. D Shortening of cell cycle

a. The rate of growth of a tumor is determined by three main factors: the doubling time of tumor cells, the fraction of tumor cells that are in the replicative pool, and the rate at which cells are shed and lost in the growing lesion.

b. The dividing cells, however, do not necessarily complete the cell cycle more rapidly than do normal cells.

c. In reality, total cell-cycle time for many tumors is equal to or longer than that of corresponding normal cells.

d. Thus, growth of tumors is not commonly associated with a shortening of cell-cycle time.

Neoplasia Flashcard List

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