Reactive oxygen intermediates in peroxisomes are produced by (AIPG 2008)
a. Peroxisomes are so named because they usually contain one or more enzymes that use molecular oxygen to remove hydrogen atoms from specific organic substrates in an oxidative reaction that produces hydrogen peroxide (H2O2).
b. Catalase enzyme in peroxisomes utilizes H2O2 generated by other enzymes in the organelle to oxidize a variety of other
c. substrates –including phenols, formic acid, formaldehyde, and alcohol by the “peroxidative ” reaction H2O2 + RH2R + 2H2O.
d. This type of oxidative reaction is particularly important in liver and kidney cells, where the peroxisomes detoxify various toxic molecules that enter the bloodstream.