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Pathology

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Immunopathology

Question
7 out of 9
 

Recurrent bacteria infection in a 8 month child is suggestive of ? (AIIMS Nov 2014)



A Isolated IgA deficiency

B Chronic granulomatous disease

C DiGeorges syndrome

D X-linked agammaglobulinemia of Bruton

Ans. D X-linked agammaglobulinemia of Bruton

a. In X linked of Bruton, B cells are absent but numbers and function of T cells are normal

b. This abnormality results from defective maturation of B lymphocytes beyond the pre-B stage.

c. This maturation defect leads to decreased or absent numbers of plasma cells, and therefore immunoglobulin levels are markedly decreased.

d. Male infants with Brutons disease begin having trouble with recurrent bacterial infections at about the age of 9 months, when maternal antibodies are no longer present in the affected infant.

e. Therapy for Brutons disease consists primarily of IV gamma globulin.

Immunopathology Flashcard List

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