Regarding Fanconi anemia, the wrong statement is: (LQ)
|B||Bone marrow show pancytopenia|
|C||Usually aplastic anemia|
|D||It is due to defective DNA repair|
Fanconi's anemia is an autosomal recessive's disease characterized by progressive pancytopenia, increased risk of malignancy (solid tumors and AMLQ) and congenital developmental anomalies like short stature, cafe au lait spots, abnormalities affecting thumb, radius and genitourinary tract.
Fanconi's anemia is associated with BRCA gene. The Fanconi anemia proteins and BRCA proteins form a DNA-dam- age repair proteins to correct intrastrand and interstrand DNA cross links induced by chemical cross-linking agents.