Regarding aprepitant all are true except (AI 2011)
|A||Agonist at N~ receptors|
|B||Crosses Blood Brain Barrier|
|C||Ameliorate nausea and vomiting induced by chemotherapy|
|D||Metabolized by CYP450 enzymes|
Aprepitant is a highly selective NKI receptor antagonist, orally active, and enter the brain.
It is used in treating and preventing chemotherapy-induced emesis.
It is metabolized by CYP3A4 enzymes and can also inhibit the metabolism of drugs metabolized by this enzyme e.g. warfarin.