Loading....
Coupon Accepted Successfully!

 

Pathogenesis

  1. Primary defect in NaCl absorption at ascending limb of the loop of Henle
  2. Volume depletion → aldosterone    - Kaliuresis
  3. More NaCl delivered to distal tubules - Hypokalemia

Hypokalemia further increase aldosterone production by stimulating release of prostaglandin E2 and 12 which promote secretion of Renin.

 

Clinical Feature:

 

Severe form of Barter syndrome [Hyper Prostaglandin E syndrome] may afflict new characterized by poly hydramnios, Prematurity, Dehydration and growth failure. Young children have growth failure, muscle weakness, constipation, polyuria.

 

Treatment:

  1. Oral potassium supplement
  2. K + sparing diuretics
  3. Indomethacin – inhibit PG synthesis
  4. B – blocker ↓  Renin level




Test Your Skills Now!
Take a Quiz now
Reviewer Name