Renal toxicity of aminoglycosides does not increase with:
|C||Concomitant penicillin administration|
|D||Prior aminoglycoside therapy|
a. About 8 - 26% of patients who receive an aminoglycoside for more than several days will develop mild renal impairment that is almost always reversible. Several variables appear to influence the nephrotoxicity from aminoglycosides.
b. Toxicity correlates with the total amount of drug administered. Neomycin is highly nephrotoxic in human beings and should not be administered systemically.
c. Streptomycin does not concentrate in the renal cortex and is least nephrotoxic.
d. Other drugs such as amphotericin-B, vancomycin, cisplatin and cyclosporine may potentiate aminoglycoside-induced nephrotoxicity. Several studies suggest that cephalothin aggravates the nephrotoxicity produced by aminoglycosides.
e. Furosemide enhances the nephrotoxicity of aminoglycosides from aminoglycosides, but data are not convincing.