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Chlamydia

  1. Three species C. trachomatis, C. psittaci, C. pneumoniae
  2. Small, obligate intracellular, gram negative, nonmotile coccobacilli
  3. Filterable through bacterial filters. Lack peptidoglycan in cell wall
  4. Lack the ability to produces ATP (therefore called as energy parasites)
  5.  Multiply in the cytoplasm of the host cell forming basophilic inclusion bodies which drape around the nucleus- a/c basophilic viruses- Giemsa, Giminez stains
  6. Susceptible to wide range of antibiotics (macrolides, tetracyclines etc.)
  7. Developmental cycle: elementary body (EB): extracellular infectious particle, 250-350nm; reticulate body (RB): intracellular, replicative form 1µm
  8. Culture: Mice, Yolk sac, cell culture (McCoy cells)
Site of infection Disease Organism Serovar
Eye Trachoma
Inclusion conjunctivitis
Ophthalmia neonatorum
C. trachomatis
C. trachomatis
C. trachomatis
A, B, Ba, C
D-K
D-K
Genital tract
Males
Females
 
Urethritis, epididymitis, proctitis
Urethritis, cervicitis, salpingitis, perihepatitis, proctitis
 
C. trachomatis
C. trachomatis
D-K
D-K
 
Respiratory tract Pneumonia in infant
Pharyngitis, pneumonia
Psittacosis
C. trachomatis
C. pneumoniae
C. psittaci
D-K
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