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Medicine

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Cardiology

Question
4 out of 67
 

Risk factors for coronary artery disease (CAD) (PGI May 2009)



A High HDL

B Low LDL

C Increased homocysteine levels

D Decreased fibrinogen levels

E Increased lipoproteins a

Ans. C

Increased homocysteine levels, E . Increased lipoproteins a

Precipitating factors

1. Fibrinogen Levels

a. 'Fibrinogen levels correlate with coronary risk and provide information regarding coronary risk independent of lipoprotein profile.

b. Elevated fibrinogen levels might promote a thrombotic diathesis '.

2. Waist Hip Ratio:

a. This refers to a characteristic 'male' distribution of adipose tissue i.e. excess of fat in the abdomen compared with that in hips.

b. 'An elevated waist/hip ratio has been associated with symptomatic cardiovascular disease and cerebrovascular disease in both men and women.

3. Hyper homocystinemia

a. There is a strong positive correlation between atherosclerosis and circulating levels of Homocysteine'

b. Major factor leading to hyperhomocysteinemia is folate deficiency

4. Hyperlipidemia

Primary Hyperlipidemia (Familial hyperlipidemia)

Condition

Risk Of Coronary Artery Disease

Type I (Familial Hyper Chylomicronemia)

Not increased

Type II A (Familial Hyper Cholesterolemia)

Accelerated

Type II B (Familial Combined Hyperlipidemia)

Accelerated

Type III (Familial Dysbetalipoproteinemia

Accelerated

Type IV (Familial Hypertriglyceridemia)

Accelerated

Type V (Familial Mixed Hypertriglyceridemia)

Not increased

Secondary hyperlipidemia

1. Hypothyroid

2. Nephrotic Syndrome

Cardiology Flashcard List

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