Autocoids (Histamine and Serotonin)
Rofecoxib as compared to indomethacin is (LQ)
|A||Less likely to cause gastric ulcer and their complica- tions|
|B||Likely to be more effective in rheumatoid arthritis|
|C||Not likely to produce renal complications|
|D||All of the above|
Selective COX-2 inhibitors are less likely to cause GI complications like PUD. However as COX-2 is also present constitutively in the kidney, chances of renal complications are similar. These drugs have similar or less efficacy than non-selective COX inhibitors.