Gram Positive Cocci
S. aureus causes a wide variety of infections, ranging from wound infection to pneumoniA. Treatment of S. aureus infection with penicillin is often complicated by the (AIPG 2010)
|A||Inability of penicillin to penetrate the membrane of S. aureus|
|B||Production of penicillinase by S. aureus|
|C||Production of penicillin acetylase by S. aureus|
|D||Lack of penicillin binding sites on S. aureus|
|E||Allergic reaction caused by staphylococcal protein|
Staphylococci are Grampositive, non-spore-forming cocci.
Clinically, their antibiotic resistance posess major problems.
Many strains produce +beta-lactamase (penicillinase), an enzyme that destroys penicillin by opening the lactam ring.
Drug resistance, mediated by plasmids, may be transferred by transduction.