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Medicine

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Cardiology

Question
26 out of 36
 

Side effect of ACEI ? (AIIMS May 11)



A Hypocalcemia
B Hyperkalemia

C Hyponatremia
D None of the above

Ans. B

Hyperkalemia

Drugs which reduce the peripheral resistance

1. Alpha blockers

2. Calcium channel blockers

3. ACEI

4. Direct vasodilators

1. Alpha blockers: They act on the peripheral alpha receptors thereby dilate the arteriole.

Examples: Prazosin,

Uses of alpha blockers in hypertension

a. Elderly Q

b. HT with BHP

c. HT with CRF

d. HT with hyperuricemia

2. Calcium channel blockers: They dilate the arteriole so reduce the peripheral resistance

Example: Nifedipine

Uses

1. Elderly hypertensive

2. HT with CRF

3. HT with PVD

4. HT with SAH (Nimodipine is used) (MCQ)


Contraindication

1. HT with CAD

2. Malignant hypertension

3. HT with CHF

New Drug: Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. (Its name is not given in 18th Edition of Harrison)

ACEI:

Examples: Captopril, Lisinopril

Uses in HT

1. Young patients

2. Unilateral renal artery stenosis

3. HT with DM

4. HT with CHF

5. HT with MI

6. HT with hyperuricemia

7. HT with erectile dysfunction


Side Effects:Cough (M/C), Hyperkalemia (LQ, AIIMS Nov 2007), Angioneurotic edema, First dose hypotension.

Captopril causes leukopenia & nephrotic syndrome.

Contraindication

1. Bilateral renal artery stenosis

2. With potassium sparing diuretics

3. CRF

4. Pregnancy

Cardiology Flashcard List

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