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Biochemistry

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Vitamins, Harmones and Hemoglobin

Question
17 out of 30
 

Somatomedin are involve in : (AIIMS May 2009)



A Activation of lipolysis

B Entry of glucose in to cell

C Activation of gluconeogenesis

D Promote deposition of chondroitin sulfate

Ans. D Promote deposition of chondroitin sulfate (Ref ; colour atlas of physiology page 280)

Skeletal growth with the aid of somatomedins (growth factors formed in the liver), which play a role in sulfate uptake by cartilage.

Somatomedin is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division . In this way, they mediate the effect of somatotropin (also known as growth hormone ).

They have similar biological effects to somatotropin.

Three forms include:

  1. Somatomedin A, which is another name for insulin-like growth factor 2
  2. Somatomedin B, which is derived from vitronectin
  3. Somatomedin C, which is another name for insulin-like growth factor 1

Somatomedin C = insulin-like growth factor-1 (IGF-1) inhibits the release of GH by the anterior pituitary via negative feedback control. GH has lipolytic and glycogenolytic actions that are independent of somatomedin activity.

Vitamins, Harmones and Hemoglobin Flashcard List

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