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Medicine

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Endocrine

Question
15 out of 20
 

Somatomedin are produce when they are stimulated by which hormone? (AIIMS Nov 2013)



A Thyroid hormone
B Growth hormone

C PTH
D Prolactin

Ans. B

Growth Hormone

Basic physiology

1). Growth hormone is also known as somatotropin.

2). Growth hormone releasing inhibitory factor (GHRIF) is also known as somatostatin.

3). Somatomedin are a group of hormone produced when stimulated by somatotropin (i.e. GH) to mediate its effects. They are:

a. Somatomedin A - also known as IGF – 2

b. Somatomedin B - Derived from vitronectin

Somatomedin C - also known as IGF –

1). It is a potent growth and differentiation factor.

4). Increase GH release occur by

a. Fasting

b. i/v L arginine

c. alpha agonist

d. dopamine

e. apomorphine

f. beta blocker

Extra Edge:

1). GH is released by GHRF

2). Somatostatin inhibits GH secretion.

3). Ghrelin is agonist for GHRF so increases GH release.

4). GH exerts its action directly or via IGF-1


Extra Edge : Mecaserminis recombinant human insulin-like growth factor 1 (IGF-I), which is used for the long-term treatment of growth failurein children with severe primary IGF-I deficiency. This drug is not to be confused with Mecasermin rinfabate, which is a combination of recombinant human IGF-1 (rhIGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3). IGFBP-3 serves to prolong the action of IGF-1 in the human body. These are new drugs, not given in 18th edition Harrison also !!!

Endocrine Flashcard List

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