Streptokinase is used as fibrinolytic. Which of the following is its mechanism of action?
|A||It activates the conversion of fibrin to fibrin-split products|
|B||It activates the conversion of plasminogen to plasmin|
|C||It inhibits the conversion prothrombin to thrombin|
|D||It inhibits the conversion of fibrinogen to fibrin|
a. Streptokinase is a bacterial product and forms a stable complex with plasminogen.
b. The resulting conformational change allows for formation of free plasmin, the active fibrinolytic enzyme. It is given as a loading dose of 1 lakh unit followed by a maintenance dose of 60,000. It is the drug of choice for acute myocardial infarction.
c. Side effects include hypotension of variable degree seen in most patients and bleeding episodes in serious patients. Repeated use of drug might reduce efficacy of drug. In patients with past streptococcal infections, the effect of drug could be reduced.