Streptomycin and other aminoglycosides inhibit bacterial protein synthesis by binding to which of the following? (AIPG 2012)
|A||30S ribosomal particles|
|D||Peptidoglycan units in the cell wall|
The bactericidal activity of streptomycin and other aminoglycosides involves a direct action on the 30S ribosomal subunit, the site at which these agents both inhibit protein synthesis and diminish the accuracy of translation of the genetic code. Proteins containing improper sequences of amino acids (known as nonsense proteins) are often nonfunctional.