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Physiology

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Central Nervous System

Question
3 out of 23
 

Substance p is released in response to pain in periphery. (AIIMS NOV 2009)



A Nerve terminals
B Mast cells

C Endothelium
D Plasma

Ans. A Nerve terminals

I. Substance P is found in high concentration in the endings of primary afferent neurons in the spinal cord Q, and it is probably the mediator at the first synapse Q in the pathways for pain transmission in the dorsal horn.

II. It is also found in high concentrations in the nigrostriatal system Q, where its concentration is proportional to that of dopamine, and in the hypothalamus, where it may play a role in neuroendocrine regulation.

III. Upon injection into the skin, it causes redness and swelling, and it is the mediator released by nerve fibers that is responsible for the axon reflex Q.

IV. In the intestine, it is involved in peristalsis Q.

a. It has recently been reported that a centrally active NK-1 receptor antagonist has antidepressant activity in humans.

Central Nervous System Flashcard List

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