Survival of allografts is increased by choosing donors with few MHC mismatches with recipients and by use of immunosuppression in recipients. Which one of the following procedure
might be useful measure of immunosup-pression ?
|A||Administration of corticosteroids to recipient|
|B||Administration of immunoglubin to recipient|
|C||Destruction of donor B cells|
|D||Destruction of donor T cells|
Allograft rejection is primarily a T cell response to foreign tissue. The corticosteroids reduce inflammatory response and are generally administered by cytotoxic drugs, such as cyclosporine. Lymphoid irradiation is usually done so that the bone mar row is shielded. This removes lymphocytes from lymph nodes and spleen while allowing the patient to have the capacity to regenerate new T and B cells. Likewise, antilymphocyte globulin will destroy the recipient’s lymphocytes, especially T cells. Destruction of donor B cells and T cells would not play a role in the immunosuppression of the graft recipient. In graft crises, monoclonal antibody to CD3 is sometimes given. This targets mature T lymphocytes for destruction.