Synovial sarcoma All true except (DNB Dec 2010)
|A||Originates in synovium|
|B||Seen in > 50 yrs|
|C||Occurs at extraarticular sites more often|
|D||Seen in sites such as knee and foot..|
Originates in synovium Ref:Campbells 11th edition
a. Synovial sarcomas can occur across a wide age range. Compared with other “adult-type” soft-tissue sarcomas, synovial sarcomas have several unique clinical features.
b. There is a greater tendency for synovial sarcomas to occur in young adults compared with the older population affected by other soft-tissue sarcomas.
c. Also, synovial sarcomas are relatively common in the distal extremities, including the hand or foot. They frequently have an indolent course initially.
d. It is common for a mass to be present for several years before coming to medical attention. Finally, synovial sarcomas frequently are relatively small (<5 cm) at presentation. This may be attributed to the fact that many patients complain of pain, rather than an enlarging mass.
e. The term synovial sarcoma is a misnomer. The term originates from the histological appearance of the cells, which can resemble synovial cells.
f. The tumors do not arise from synovial tissue, however. An intraarticular location or even continuity with the joint capsule is extremely rare.
g. Plain radiographs frequently show amorphic calcification within the tumor. Microscopically, the tumors frequently show a biphasic growth pattern with nests of epithelioid cells surrounded by spindle cells.