Tetracycline have a therapeutic role in treatment of osteoarthritis this is because of
|A||Its antibacterial action reduces synovial inflammation|
|B||It actually has no role the above statement is wrong|
|C||It inactivates the matrix metalloproteinases and thus protects the cartilage|
|D||It forms a protective layer on the cartilage and prevents degradation|
It inactivates the matrix metalloproteinases and thus protects the cartilage
a. Tetracyclines are potent inhibitors of matrix metalloproateinases (MMP) and chemically modified tetracyclines having no antibacterial action but with ability to inactivate MMPs seem to be promising as disease modifying agent in osteoarthritis.
b. The chondrocyte secretes numerous MMPs which include stromyelin collagenase, gelatinase etc which can destroy the whole cartilage network)