Thalidomide not used in: (DNB June 2011)
|A||HIV associated neuropathy|
|C||HIV associated oral ulcers|
a. Thalidomide is the drug of choice for type-II lepra reaction and is also known as ENL. The drug has been used in Beh|et’s disease with some success.
b. It appears to be a great potential for patients with severe ulcers in mouth.
c. It has also been tried in HIV associated colitis and HIV induced wasting.
d. Neuropathy is a side effect of thalidomide and not a therapeutic indication. It is partially reversible in 50% of cases, suggesting a sensory ganglionopathy.