The Amikacin differs from gentamicin mainly in that it: (AIIME Nov 2012)
|A||Does not require monitoring of blood levels during therapy|
|B||Exerts significant bactericidal effects against anaerobes too|
|C||Has broadest spectrum against gram-negative bacilli|
|D||Lacks ototoxic potential|
a. Amikacin stands out among all the aminoglycosides in two main ways: it has the broadest spectrum against gram-negative bacilli, and it is least susceptible to bacterial enzymes that inactivate aminoglycosides and lead to resistance.
b. (Recall that among gram-negative bacteria, genetic information that codes for the production of these inactivating enzymes is transferred via R factors.)