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Anatomy

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Histology

Question
50 out of 59
 

The corneal transparency is maintained by (LQ)



A Keratocytes
B Bowman's membrane

C Descemet's membrane
D Endothelium

Ans. D

Endothelium

1. The cornea has unmyelinated nerve endings sensitive to touch, temperature and chemicals; a touch of the cornea causes an involuntary reflex to close the eyelid.

2. Because transparency is of prime importance the cornea does not have blood vessels; it receives nutrients via diffusion from the tear fluid at the outside and the aqueous humour at the inside and also from neurotrophins supplied by nerve fibres that innervate it.

3. From the anterior to posterior the 5 corneal layers are:

a. Corneal epithelium: a thin epithelial multicellular (stratified squamous non-keratinised) layer of fast-growing and easily-regenerated cells, kept moist with tears.

i. Irregularity or edema of the corneal epithelium disrupts the smoothness of the air-tear film interface, the most significant component of the total refractive power of the eye, thereby reducing visual acuity.

b. Bowman's layer (also erroneously known as the anterior limiting membrane, when in fact it is not a membrane but a condensed layer of collagen): a tough layer that protects the corneal stroma, consisting of irregularly-arranged collagen fibers.

c. Corneal stroma (also substantia propria): a thick, transparent middle layer, consisting of regularly-arranged collagen fibers along with sparsely populated keratocytes.

There are 2 theories of how transparency in the cornea comes about:

i. The lattice arrangements of the collagen fibrils in the stroma. The light scatter by individual fibrils is cancelled by destructive interference from the scattered light from other individual fibrils.

ii. The spacing of the neighbouring collagen fibrils in the stroma must be < 200 nm for there to be transparency.

d. Descemet's membrane (also posterior limiting membrane): a thin acellular layer that serves as the modified basement membrane of the corneal endothelium.

e. Corneal endothelium: a simple squamous or low cuboidal monolayer of mitochondria-rich cells responsible for regulating fluid and solute transport between the aqueous and corneal stromal compartments and thus maintaining corneal transparency. (The term endothelium is a misnomer here. The corneal endothelium is bathed by aqueous humour, not by blood or lymph, and has a very different origin, function, and appearance from vascular endothelia.)

Histology Flashcard List

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