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The crush syndrome may occur if a large bulk of muscle is crushed as by fallen masonry or if a tourniquet has been left on too long. The etiopathogenesis may be (AIPG 2011)
|A||Release of cardiotoxins after release of compression.|
|B||Release of acid myohaematin (cytochrome C from muscle break down, which is then carried to the kidneys and blocks the tubules).|
|C||Formation of antibodies to muscle tissue.|
|D||Release of myoglobin which blocks the portal vein thus causing cir¬rhosis of liver.|
Release of acid myohaematin (cytochrome C. from muscle break down, which is then carried to the kidneys and blocks the tubules
An alternative explanation is that renal artery spasm occurs and the anoxic tubules necrose.