The Endocrine System
The feature that differentiates a follicular carcinoma from a follicular adenoma of thyroid is? (AIPG 2010)
|B||Hurthle cell change|
|D||Absence of colloid|
a. Differentiating features of follicular adenoma from follicular carcinoma:
i. The hallmark of all follicular adenomas is the presence of on intact, wall-formed capsule encircling the tumor.
b. Differentiation offollicular adenoma from multinodular goiter
i. Multinodular goiter lacks well formed capsule while follicular adenoma has well-formed capsule.
ii. pattern within the adenoma is distinct from the adjacent non- neoplastic thyroid.
iii. Multinodular goiter produces less compression of the adjacent thyroid parenchyma, while follicular adenoma compresses the adjacent thyroid.
iv. In multinodular goiter the involved and uninvolved (normal) thyroid have similar growth pattern. On the other hand growth
v. Careful evaluation of the integrity of the capsule is therefore critical in distinguishing follicular adenomas from follicular carcinomas which demonstrate capsular and lor vascular invasion.
vi. Hurthle cells are seen both in follicular adenomas and follicular carcinoma