Gram Negative Bacilli
The fluoroquinolone resistance seen with increasing frequency in Pseudomonas aeruginosa infections is best explained by which of the following mechanisms?
|A||Changes in the structure or composition of the cell envelope that make it more difficult for the antibiotic to gain entrance|
|B||Enzymatic cleavage of the antibiotic molecule|
|C||Inactivation of the antibiotic by enzymatic acetylation|
|D||Removal of the antibiotic from the cell interior by a membrane pump|
Resistance to fluoroquinolones is mediated by endogenous multidrug efflux pumps or drug target alterations, i.e DNA gyrase and topoisomerase.