The following changes in plasma concentration of warfarin were observed In a patient when 2 other agents, drugs Band C, were given on. a daily basis at constant dosage starting at the times shown, Which of the following statements most accurately describes what is shown in the graph below? (AIPG 2012)
|A||Drug B displaces warfarin' from plasma proteins; drug C displaces warfarin from tissue binding sites|
|B||Drug B inhibits hepatic metabolism of warfarin; drug C displaces drug B from tissue binding sites|
|C||Drug B stimulates hepatic metabolism of warfarin; drug C displaces warfarin from plasma protein|
|D||Drug B increases renal clearance of warfarin; drug C inhibits hepatic metabolism of drug B|
a. A drug that increases metabolism (clearance) of the anticoagulant will lower the steady-state plasma concentration (both free and bound forms), whereas one that displaces the anticoagulant will increase the plasma level of the free form only until elimination of the drug has again lowered it to the steady-state level.