The following drug can be given safely in pregnancy: (AIPG 2009)
1. The goal of treatment in hyperthyroidism in pregnancy is to maintain clinical euthyroidism, with the mother’s FT4 level kept in the high-normal range.
2. Thioamide drugs are first-line treatment in pregnancy. Propylthiourcil (PTU), methimazole, and carbimazole are anti-thyroid drugs generally used.
3. These drugs inhibit iodination of thyroglobulin and thyroglobulin synthesis by competing with iodine for the enzyme peroxidase.
4. Methimazole is known to be associated with fetal scalp defects, aplastic cutis, and choanal and/or esophageal atresia.
5. Therefore, PTU tends to be the first choice in this class of drugs. Beta-blockers (e.g. atenolol, nadolol, propranolol) are valuable adjuncts to ATDs.
6. (Beta-blockers are associated with fetal morbidity. Therefore, these drugs should be used for only a short period which is not more than 2 wk) Methtrexate, Warfarin and Tetracycline are contraindicated drugs in pregnancy and are the category ‘X’ of pregnancy, which are teratogenic in nature and their benefits are outweighed by their teratogenic
7. Side effects.