The following is an antiapoptotic gene – (AIPG 2011)
a. Clinical importance of these genes.
i. Inhibition of apoptosis results in uncontrolled cell proliferation and cancer.
b. Human papilloma virus and cervical cancer.
i. P53 protein is proapoptotic gene, i.e., it induces apoptosis.
ii. HPV produce a protein E6 that binds and inactivates p53 → ↓ Apoptosis → ↑ Cell survival and growth → Cervical carcinoma.
c. EBV and B-cell lymphoma
i. EBV produces a protein like BCL-2. ii. BCL-2 inhibits apoptosis → B - cell lymphoma.
iii. Some other B-cell lymphomas also have high expression of BCl- 2.
i. In this tumor, there is decreased expression of Apaf-1.
ii. Apaf-1 is an antiapoptotic protein, Its decreased expression induce apoptosis and malignancy.