The following is an example of “Regulated pathway”(DNB Pattern)
|B||Receptor mediated endocytosis|
|D||Non constitutive exocytosis|
- This extrusion process, requires Ca++ and energy, along with docking proteins.
- There are two pathway by which secretion from the cell occurs: -
i. Non constitutive pathway → proteins from the golgi apparatus initially enter secretory granules, where processing of prohormones to the mature hormones occurs before exocytosis.
ii. Constitutive pathway → prompt transport of proteins to the cell membrane in vesicles, with little or no processing or storage.
- The non constitutive pathway is sometimes called the regulated pathway, but this term is misleading because the output of protiens by the constitutive pathway is also regulated.