The following laboratory determinants is abnormally prolonged in ITP: (AIPG 2011)
1. In children: Typically presents 2 – 3 weeks after a viral infection with sudden onset of purpura, nasal or oral bleeding.
2. In adults: ITP involves females more commonly and has insidious onset. Symptoms and signs of collagen vascular disorders (like rheumatoid arthritis) may be present. The course is chronic with remissions and relapses.
3. Splenomegaly and bleeding in the joints are not the feature of ITP.
Difference between acute of chrome ITP
14. Ans. B.
1. In children, the disease is usually self – limiting within a few weeks.
2. Drugs therapy a. Prednisolone b. Intravenous immunoglobulin
1. Platelet transfusion is not effective because in ITP, thrombocytopenia is caused by immune mediated destruction of platelet.
2. Most common cause of death- cerebral hemorrhage.
Recent Advances: (Ref. Hari-18th Pg.-969)
1. Two agents thrombopoietin receptor agonists (TPO receptor agonist,) have shown response in many patients with refractory ITP.
a. Romiplostim (Givensubcutaneously)
b. Eltrombopag (Oral)