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Pathology

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Neoplasia

Question
7 out of 24
 

The following statements are true about Tumour suppressor Gene p53 except: (AIIMS May 2013)



A It regulates certain genes involved in cell cycle regulation

B Its increased levels can induce apoptosis

C Its activity in the cells decreases following UV irradiation and stimulates cell cycle

D Mutations of the p53 gene are the most common genetic alteration seen in human cancer

Ans. C i.e. Its activity in the cells decreases following UV irradiation and stimulates cell cycle

Remember

a. Most common target for genetic alteration in human tumors is P53 (a little over 50% of human tumors contain mutation in this gene).

b. Most common target for genetic alteration among protooncogene is ras.

c. Most common target for genetic alteration among nuclear regulatory proteins is myc.

d. Most common target for genetic alteration among cell cycle regulators is CDK-4

Neoplasia Flashcard List

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