The immunosuppressant action of cyclosporine appears to be due to (LQ)
|A||Activation of NK cells|
|B||Blockade of tissue responses to inflammatory mediators|
|C||Inhibition of gene transcription of interleukins|
|D||Interference with antigen recognition|
· Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NF-AT. Final result of this process is increased transcription of IL-2 gene.
· Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR (which is activated by IL-2).