The lymphocytopenia seen a few hours after administration of a large dose of prednisone to a patient with lymphocytic leukemia is due to (LQ)
|A||Massive lymphocytic apoptosis|
|B||Bone marrow depression|
|C||Activation of cytotoxic cells|
|D||Stimulation of natural killer cell activity|
Activation of programma cell death (apoptosis) in certain lymphoid tissues
Redistribution of lymphocytes, eosinophiles, monocytes and basophils away from the periphery. It leads to decrease in these cell counts within 4-6 hours.
Increased release of neutrophils from marrow diminished rate of removal from the circulation and increased demargination form vascular walls.