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Pathology

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CVS

Question
13 out of 17
 

The mechanism of the development of Acute Rheumatic Fever is which of the following? (AIPG 2012)



A Cross reactivity with exogenous antigen

B Innocent bystander effect

C Due to toxin secretion by streptococci

D Release of pyrogenic cytokines

Ans. A Cross reactivity with exogenous antigen

Acute rheumatic fever results from immune response to group A streptococci (Strep. pyogenes) which cross-reacts within host tissues. The antibodies directed against the M proteins of streptococci cross reacts with the self antigens in the heart. In addition, CD4+ T cells specific for streptococcal peptides also react with self proteins in the heart and produce macrophage activating cytokines. So, the damage to the heart tissue is a combination of antibody and T-cell mediated reactions.

CVS Flashcard List

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