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Pathology

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Inflammation

Question
2 out of 13
 

The most common cause of chronic granulomatous disease is ? (AIPG 2011)



A Defect in the enzyme NADPH oxidase

B Defect in the enzyme adenosine deaminase (ADA)

C Defect in the IL-2 receptor

D Developmental defect at the pre-B stage

Ans. A Defect in the enzyme NADPH oxidase

a. The most common cause of chronic granulomatous disease is defective NADPH oxidase, which is an enzyme on the membrane of lysosomes that converts O2 to superoxide and stimulates oxygen burst.

b. This deficiency results in recurrent infections with catalase positive organisms, such as S. aureus.

c. A defect in the enzyme adenosine deaminase (ADA) is seen in the autosomal recessive (Swiss) form of severe combined immunodeficiency disease (SCID), while a defect in the IL-2 receptor is seen in the X-linked recessive form of SCID.

d. A developmental defect at the pre-B stage is seen in X-linked agammaglobulinemia of Bruton, while developmental failure of pharyngeal pouches 3 and 4 is characteristic of DiGeorges syndrome.

Inflammation Flashcard List

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