The most common site of distant metastases from a primary breast carcinoma is:
a. Successful implantation of metastatic foci from breast cancer predictably occurs after the primary cancer exceeds 0.5 cm in diameter, which corresponds to the twenty-seventh cell doubling.
b. For 10 years following initial treatment, distant metastases are the most common cause of death in breast cancer patients. For this reason, conclusive results cannot be derived from breast cancer trials until at least 5 to 10 years have elapsed.
c. While 60% of the women who develop distant metastases will do so within 24 months of treatment, metastases may become evident as late as 20 to 30 years after treatment of the primary cancer.
d. Common sites of involvement, in order of frequency, are bone, lung, pleura, soft tissues, and liver.