The most common site of occurrence of peptic ulcer is: (AIIMS Nov 2010)
|A||Anterior wall of first part of duodenum|
|B||Posterior wall of first part of duodenum|
|C||Second part of duodenum|
|D||Antral region of stomach along lesser curvature|
b. They are usually 1 cm in diameter but can occasionally reach 3–6 cm (giant ulcer).
c. Ulcers are sharply demarcated, with depth at times reaching the muscularis propria. The base of the ulcer often consists of a zone of eosinophilic necrosis with surrounding fibrosis.
d. Malignant DUs are extremely rare.
b. Benign GUs are most often found distal to the junction between the antrum and the acid secretory mucosa.
c. Benign GUs are quite rare in the gastric fundus and are histologically similar to DUs.
d. Benign GUs associated with H. pylori are also associated with antral gastritis.
e. In contrast, NSAID-related GUs are not accompanied by chronic active gastritis but may instead have evidence of a chemical gastropathy, typified by foveolar hyperplasia, edema of the lamina propria and epithelial regeneration in the absence of H. pylori.
f. Extension of smooth-muscle fibers into the upper portions of the mucosa, where they are not typically found, may also occur.