The most important structural component of connective tissue is collagen. Which of the following statement(s) is/are true concerning types of collagen?
|A||All collagen is fiber forming|
|B||Type 1 collagen is the most abundant in the human body|
|C||Type 2 collagen is found in cartilage|
|D||The basement membrane collagens, type 4 and 5, do not form regular fibers|
At least 15 separate collagen molecules have been identified, each with a specific confirmation associated with a unique kinetic or mechanical property.
a. The collagens can be categorized into two major groups—fiber-forming collagens and collagens that do not form regular fibers.
b. The fiber-forming collagens include Type 1, Type 2, and Type 3. Type 1 collagen is the most abundant in the human body and is the dominant constituent in tendons, ligaments, bone, skin, vessel walls, and scar and granulation tissues.
c. Type 2 collagen is found in the cartilage and Type 3 collagen is found in tendon and ligament sheaths, as well as in muscle, skin, blood vessel walls, and scar tissue.
d. The remaining collagens do not form regular fibers and include the basement membrane collagens, Types 4 and 5.