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Biochemistry

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Carbohydrates

Question
3 out of 40
 

The most likely cause of the hemolysis is a less than normal level of which of the following?



A Glucose 6-phosphate

B Oxidized form of NAD

C Reduced form of glutathione

D Ribose 5 phosphate

Ans. C Reduced form of glutathione

a. Glutathione is essential for red cell integrity and is maintained in its function (reduced) form by NADPH dependent glutathione reductase.

b. The NADPH is generated by the oxidative portion of pentose phosphate pathway. Individuals with a deficiency of the initiating and regulated enzyme (G6PD) of this pathway have a decreased ability to generate NADPH, and thus a decreased ability to keep glutathione functional.

c. When treated with an oxidant drug such as primaquine, some patients with G6PD deficiency develop and hemolytic anemia.

d. Primaquine does not affect glucose 6-phosphate levels. NAD+ is neither produced by the pentose phosphate pathway nor used as a coenzyme by glutathione reductase.

e. Ribulose 5-phosphate, another product of the oxidative portion of the pentose phosphate pathway, can be isomerized to ribose 5-phosphate, but a deficiency in either does not cause hemolysis.

Carbohydrates Flashcard List

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