The most likely mechanism involved in the antiseizure activity of carbamazepine is (LQ)
|A||Block of sodium ion channels|
|B||Block of calcium ion channels|
|C||Facilitation of GABA actions on chloride ion channels|
|D||Glutamate receptor antagonism|
a. Carbamazepine's mechanism of action is similar to that of phenytoin, blocking sodium ion channels.
b. Ethosuximide blocks calcium channels; benzodiazepines and barbiturates facilitate the inhibitory actions of GABA;
c. Topiramate may block glutamate receptors; and
d. Vigabatrin inhibits GABA metabolism.