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Pathology

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Neoplasia

Question
15 out of 24
 

The normal cellular counterparts of oncogenes are Important for the following functions except: (AIPG 2011)



A Promotion of cell cycle progression

B Inhibition of apoptosis

C Promotion of DNA repair

D Promotion of nuclear transcription

Ans. C i.e. Promotion of DNA repair

a. Oncogenes are genes that promote autonomous cell growth in cancer.

b. The are derived from their normal cellular counterparts called as protooncogene which are physiologic regulators of cell proliferation and differentiation.

c. Oncogenesis promote cell growth in the absence of normal mitogenic signals.

1. Functions of oncogenes are:

i. Act as growth factor eg SIS, int, hst

ii. Act as growth factor receptor eg erb-B, erb-B2 (Her 2/neu)

iii. Act as signal transduction/relay factors e.g. ret

iv. Act as transcription factors eg myc

v. Cell cycle controller eg bcl-1 (PRAD1), mdm-2 (P53 antagonist)

vi. Apoptosis blocker eg bcl-2.

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