Autocoids (Histamine and Serotonin)
The plasma half life of aspirin (LQ)
|A||Is independent of dose|
|B||Is longer for anti-inflammatory doses compared to that for analgesic dose|
|C||Is shorter for anti-inflammatory doses compared to that for analgesic dose|
|D||Can be increased by alkalinizing the urine|
Aspirin and other salicylates show saturation kinetics (zero order) and thus, their half-life is not constant. Clearance at high doses (anti-inflammatory) is lesser than at low (analgesic) doses. Thus tl/2 is more for anti-inflammatory dose than for analgesic dose.