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Medicine

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Hematology

Question
4 out of 16
 

The presence of small sized platelets on the peripheral smear is characteristic of: (AIIMS Nov. 2010)



A Idiopathic thrombocytopenic purpura

B Bernard Soulier syndrome

C Disseminated intravascular coagulation

D Wiskott Aldrich syndrome

Ans. D

Wiskott Aldrich syndrome

Wiskott Aldrich Syndrome (W AS) (X linked Recessive inheritance)

Characteristic Triad

1. Eczema

2. Thrombocytopenia

a. Repeated Bleeding episodes

b. Small Platelet size (characteristic)

c. Number and morphology of Megakaryocytes in marrow is normal)

d. Impaired platelet aggregation response

3, Immunodeficiency

a. Repeated Infections

b. Immunodeficiency in WAS

i. IgM

ii. IgE

iii. IgA and IgG are usually normal

iv. antibody response to unconjugated polysaccharide antigens and protein antigens

v. T cell (Acquired T deficiency) (eventually acquire severe T cell deficiency)

Hematology Flashcard List

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