The primary pathologic effect of polioviral infection is a result of which of the following: (AIIMS Nov 2011)
|A||Destruction of infected cells|
|B||Paralysis of muscle cells|
|C||Immune complex formation|
a. Polioviruses are cytolytic and cause direct damage to infected cells; answers B, C, D are incorrect:
b. Paralysis results in less than 2 percent of patients infected with poliovirus and is a direct result of the destruction of infected neurons in the spinal cord and brain;
c. Paralytic disease is caused by cytolytic damage because of the virus, not by the immune response;
d. Aseptic meningitis is a result of poliovirus infection which occurs in less than 1-2 percent of patients infected, and is a result of the destruction of infected cells.