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Physiology

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Kidney

Question
7 out of 7
 

The renal plasma flow (RPF) of a patient was to be estimated through the measurement of Para Amino Hippuric acid (PAH) clearance. The technician observed the procedures correctly but due to an error in the weighing inadvertently used thrice the recommended dose of PAH. RPF estimated is likely to be:



A False — High

B False — Low

C False — high or false — low depending on the GFR

D Correct and is unaffected by the PAH overdose

Ans. B False — LowParaaminohippuric acid is used to measure renal plasma flow Q.

I. At low plasma cone of PAH, it is almost completely cleared from the plasma by a combination of glomerular filtration and tubular secretion, and indicates renal plasma flow.

II. When plasma cone of PAH is elevated beyond 20 mg/dL, the secretary mechanism becomes saturated, and the transport maximum (Tm) is reached. So the clearance of PAR from plasma is decreased, giving a false low value of RPF.

Kidney Flashcard List

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