The safest drug in pregnancy is (LQ)
Isoniazid - INH is well tolerated by most patients
a. Peripheral neuritis and variety of neurological manifestation (paresthesia, numbness, mental disturbances, rarely convulsion are most dose dependent toxic effects
b. Hepatitis is major adverse effect of INH is rare in children but more common in older people and alcoholics, It is due to dose related damage to live cells and is reversible on stopping the drugs.