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Biochemistry

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Vitamins, Harmones and Hemoglobin

Question
25 out of 30
 

Thiamine deficiency seen in all except (AIIMS May

2007)



A Food faddist

B Alcoholic

C Chronic diarrhea.

D Homocystinemia

Ans. D Food faddist

a. Thiamine or vitamin B1 deficiency is not related to homocystinemia.

b. Homocystinemia is an inborn error of metabolism.

c. Homocysteine has two fates:

d. One is getting converted to cystathionine for the formation of homoserine, the enzyme being cystathionine beta synthase, which requires 86 as coenzyme.

e. Homocysteine + serine ~ cystathionine ~ homoserine + cysteine

f. When this enzyme is defective, homocystinemia type I results, for which pyridoxine can be given to improve the prognosis.

g. The other fate is getting converted to methionine in the presence of homocysteine methyl transferase which requires 812 as coenzyme, when this enzyme becomes defective homocystinemia type II results, for which vit 812 can be given to improve the prognosis. Thus both types have got nothing related to thiamine.

h. Regarding the other choices,

i. Who is a food faddist?

j. A person who indulges in crazy food habits for a brief period of time because of which they succumb to essential nutrient deficiency like thiamine deficiency.

k. An alcoholic is always overloaded with energy (ATPs), be­cause, alcohol on getting metabolized by alcohol dehydroge­nase, gives, 1 NADH (3 ATPs) and aldehyde and when aldehyde dehydrogenase acts on it 1 more NADH (3 ATPs). Hence they never feel the hunger and they thrive on poor food habits and hence suffer from essential nutrient deficiency.

l. Chronic diarrhea, because of malabsorption, causes essential nutrient deficiency.

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